Though the Omicron variant of COVID-19 doesn’t carry a prion region in its spike protein, the original Wuhan COVID-19 variant had one. Therefore, when the Wuhan variant’s spike protein gene information was made into a vaccine as part of mRNA and adenoviral DNA vaccines, the prion region was also incorporated. A U.S. study published in the journal Microorganisms indicated that the prion area is able to interact with human cells.（COVID-19 のオミクロン変異種はスパイクタンパク質にプリオン領域を持っていないが、元の武漢型 COVID-19バリアントにはプリオン領域があった。したがって、武漢型のスパイクタンパク質遺伝子情報が mRNAワクチンおよび、アデノウイルスDNAワクチンの一部としてワクチン精製された際には、プリオン領域も組み込まれた。科学誌Microorganismsに掲載された以前のアメリカでの研究は、プリオン領域がヒト細胞と相互作用する可能性があることが示された）
Though major health organizations say genetic material from the vaccines isn’t incorporated into human DNA, mRNA studies conducted on human cells in labs have found that mRNA can be transcribed into DNA and then incorporated into the human genome.Unfortunately, the biological process of translating mRNA information into proteins isn’t perfect nor immune to mistakes, and protein misfolding can occur.（主要な世界の保健機関は、これらのワクチンの遺伝物質はヒトDNAに組み込まれていないと述べているが、研究室でヒト細胞に対して行われたmRNA研究では、 mRNAがDNAに転写され、ヒトゲノムに組み込まれることがわかっている。残念ながら、mRNA情報をタンパク質に翻訳する生物学的プロセスは完全ではなく、タンパク質の誤った折り畳みが発生する可能性がある）
Another U.S. study, published in the International Journal of Vaccine Theory, Practice, and Research, speculated that a misfolded spike protein could, in turn, create a misfolded prion region that may be able to interact with healthy prions to cause damage, leading to CJD disease.（International Journal of Vaccine Theory、Practice、and Researchに掲載された別の米国の研究では、誤って折りたたまれたスパイクタンパク質が誤って折りたたまれたプリオン領域を作成し、健康なプリオンと相互作用して損傷を引き起こし、CJDにつながる可能性があると推測している）
The French study identified 26 cases across Europe and the United States. Twenty of the individuals had already died by the time the study was written, with death occurring, on average, 4.76 months after being vaccinated.（フランスの研究では、ヨーロッパと米国全体で26のCJD症例が特定された。研究が書かれるまでに20人の個人がすでに死亡しており、ワクチン接種後平均 4.76ヶ月で死亡した）
The study’s lead author, Dr. Jean-Claude Perez, informed The Epoch Times on June 6 by email that all 26 patients had died.（この研究の筆頭著者であるジャン・クロード・ペレス博士は、6月6日に私たちエポックタイムズ（大紀元時報）に26人の患者全員が死亡したことを電子メールで通知した）
The Parties may, by unanimous agreement, invite any other European State in a position to further the principles of this Treaty and to contribute to the security of the North Atlantic area to accede to this Treaty. Any State so invited may become a Party to the Treaty by depositing its instrument of accession with the Government of the United States of America. The Government of the United States of America will inform each of the Parties of the deposit of each such instrument of accession.
This Treaty shall be ratified and its provisions carried out by the Parties in accordance with their respective constitutional processes. The instruments of ratification shall be deposited as soon as possible with the Government of the United States of America, which will notify all the other signatories of each deposit. The Treaty shall enter into force between the States which have ratified it as soon as the ratifications of the majority of the signatories, including the ratifications of Belgium, Canada, France, Luxembourg, the Netherlands, the United Kingdom and the United States, have been deposited and shall come into effect with respect to other States on the date of the deposit of their ratifications.
· state of the purpose of the essay/writing
· establishing the desirability of the research
· listing the research questions or hypotheses
· providing a synopsis of the research method(s)
· defining certain key terms
X is a fundamental property of ….
X plays an important role in the maintenance of ….
The narrative seems to have grown of late that the only reason the Russian forces aren't pushing forward faster and further is because of a lack of fuel for vehicles and food for its troops. This is exemplified by the discussion around "the column" north of Kyiv.
But that does a disservice in some respects to the thousands of Ukrainian troops fighting a bitter battle in front of the Russians. Yes, the supply problems are not helping Russia, but it's simply not the case that if they just had fuel they would be able to advance unhindered
There are many brigades holding the line around and inside Kyiv, providing a blocking force that is putting up a determined resistance to the Russian advances. This is not just scattered handfuls of SF and near partisan forces, this is several brigades of regular troops
Similarly, to the east of Kyiv there is something on the order of at least 8, and as many as 12-13 brigades, regular and reserve, holding a line that runs roughly to Kharkiv, down to the Donbas front, to Mariupol and back towards Zaporizhzhia.
That, arguably more so than logistic issues, is what has been holding the Russian tide back this long. Strung out their elements may be, but they're still providing a determined resistance across the majority of the front. The problem is for how long?
As much as they've been taking a toll on the Russians, they've been suffering casualties of their own, expending stocks of ammunition and losing critical equipment like tanks, artillery, and other armoured vehicles.
Even the Ukrainian defence ministry seems worried about the build up of Russian forces occuring in front of these positions and the fraility of their defensive line. Despite the stream of images of burning or captured Russian kit they've been advancing steadily this whole time
And while everyone focuses on Kyiv and the idea that the Russians are planning to storm the city block by block (which seems highly unlikely when they can just shell it to pieces from the outside), a lot of people have been missing the real danger in the east and south.
One area of interest is the Russian build up to the west of Kharkiv, which seems likely to result in a push towards Poltava and behind it, Kremenchuk, home to one of the few bridges across the Dnieper from there all the way south to Zaporizhzhia.
To the east of that, there is serious concern about a possible Russian thrust in the region around Izyum-Slovyansk-Severodonetsk, with the real risk of some Ukrainian forces being pocketed in the later
Equally as concerning, Russian forces have moved up to the area around Vasylivka-Orikhiv and are poised to move on Zaporizhzhia, which possesses the southern most bridge across the Dnieper available to the Ukrainians.
Not that this bridge doesn't need to be captured, nor even the city. The Russians merely have to get close enough to deny its use through artillery and direct fire as a supply route to their forces in the east.
This leaves the many brigades operating east of Kharkiv (possibly as many as 8) in a dire situation, where the only line of communication to the west of the Dnieper for all the brigades would be in the Dnipro/Kamianske region.
If they wait too late to try and make a break for the bridges, this will involve a running battle with the Russians across some pretty good tank country, with multiple Ukrainian brigades having to bunch together and cram themselves across four or five bridges in the region
To make matters worse, Mariupol is not expected to be able to hold for more than another four or five days, after which the forces surrounding it will be free to join the offensive north. In short, things are getting a bit dicey in the east.
They're not much better in the south, with Russian forces closing around Mykolaiv. The defenders are putting up a brave resistance, but inexorably being pushed back. Russian forces have already pushed on to the north and reached the area around Voznesens'k.
The latter course actually seems more likely as a force attacking Odesa more directly would be left miles from friendly forces and dependent on over the beach supply lines, whereas an attack just behind Mykolaiv would help support the assault there and be closer to friendlies
And again, herein lies part of the problem with the Kyiv narrative, and the idea that victory will be defined by the capture or not of the capital. If Odesa falls and the Russians secure the entire southern coast line, that is a major problem for Ukraine and its economy
Obviously, I mean outside of the war itself, thinking ahead to the potential peace. If Russia maintains control of all these areas in a negotiation then they basically have Ukraine by the balls, so to speak. This in many ways is far more important than Kyiv
Thus I think we need to temper our expectations. The Ukrainians have done brilliantly, better than almost anyone expected, but we're gradually creeping towards the decisive moment and none of that has much to do with what's happening around the capital.
Slow Russian progress there is encouraging and that's helping to keep aid corridors open to the east, but I fear people are putting far too much emphasis on it just because it's the biggest city and the centre of government. Russia doesn't need to seize Kyiv to "win"
The fights in the south and east are far more important in the grand scheme of things, and unfortunately those seem to be the ones the Russians are winning, albeit it slowly. If the east in particular collapses, that frees up an enormous number of Russian men and equipment
Men and guns that can be shifted west and south, to Kyiv and/or Odesa as required. It's a grim outlook I'm afraid, but I wish the Ukrainian defenders the very best of luck. It's possible they can still carry the day, but it looks like it might take some kind of miracle 😞 /end
The name's popularity decreased rapidly after Amazon picked it as the wake word of its voice service Amazon Alexa, which was released worldwide in 2016. Now, with Amazon making it their goal to implement their smart assistants into every consumers homes, people like Alexa A., a Bay Area resident, explains the impact, trauma, and teasing she lives with everyday by sharing a name with a computer: "I hate my name now, thank you so much Amazon for making everyone tease me with their annoying Alexa jokes" (Bay Area Star).
石光直樹，リクルート（2021 年 06 月 04 日）
ηC was significantly decreased from 93% (at 0% O2) to 6% (at 7% O2) with an increase in the oxygen concentration due to selective O2 reduction (O2 → O2−) competing with CO2 reduction. Therefore, a system was developed to enhance the CO2 reduction selectivity over RuCP, even in the presence of O2. A porous carbon cloth (CC) sheet made of carbon fiber was applied, which possesses a low activity for hydrogen generation (Fig. S3, ESI†), and a surface area that is two orders of magnitude larger than that of the flat and smooth surface of a conventional semiconductor film. ηC for formate formation over RuCP coated onto CC (CC/p-RuCP) is also shown in Fig. 1A. CO2 photoreduction reaction was conducted at +1.41 V (vs. RHE). An ηC of 76% was observed, even in the presence of 7% O2.
Four years after the Fukushima accident, TC screening data from the first and second round (up to December 2014) were compared with the Japanese nationwide annual TC incidence, and with the incidence in one area of Fukushima prefecture selected as reference (Tsuda et al., 2016). The authors reported that the observed number of TCs was substantially higher than the expected number based on national and regional incidence data, and concluded that this increase could be attributed to ionizing radiation exposure from the accident. This ecological study has been strongly criticized by scientists around the world because of serious methodology limitations; further, the study conclusions are not supported by the results (Davis, 2016, Jorgensen, 2016, Korblein, 2016, Shibata, 2016, Suzuki, 2016, Takahashi et al., 2016, Takamura, 2016, Wakeford et al., 2016). Limitations of ecological study design are well-known, although the authors did not acknowledge the issue of ecologic fallacy. Another criticism was that the data from the Fukushima screening program are not directly comparable with the cancer registry data from the rest of Japan where systematic advanced ultrasound technology is not used to detect cases. The authors of these criticisms suggested that though the increased TC number could be associated with the exposure from radioactive fallout, a more plausible conclusion would be that the screening program is finding an anticipated increase in TC detection across the Fukushima prefecture. Indeed, Tsuda and colleagues did not consider the latent properties of TC, nor the fact that a prevalent cancer detected by screening might have had first preclinical manifestations of abnormality before the nuclear accident.Thereafter, several researchers have analysed the relationship between radiation exposure (with different estimated exposure levels, mostly using an external dose) and TC prevalence and incidence in residents aged ≤18 years in the Fukushima prefecture at time of the disaster (Kato, 2019, Nakaya et al., 2018, Ohira et al., 2019a, Ohira et al., 2020, Ohira et al., 2019b, Ohira et al., 2016, Ohira et al., 2018, Suzuki et al., 2016, Toki et al., 2020, Yamamoto et al., 2019), but no radiation-related risks have been demonstrated to date.
In the US, people usually speak street names. For example, when you ask someone "where is that great sandwich store?" they will say "It's 18th-mission." or something. This indicates the location of the store is around the crossing corner of two streets, 18th and Mission. Just an example but I mean the way of speaking locations heavily depends on the culture and conventions of the area or country. No implication in it.
次回 : Part-8 https://anond.hatelabo.jp/20201018143903
|RSU\Year||Year 1||Year 2||Year 3||Year 4||Year 5|
大手で言えばAmazonが後者に当てはまる。AmazonではRefresherがtarget TCに基づいて発行される。Realized compensationがtarget TCに「なるように」refresherの発行数を決めるのだ。株価上昇ですでにRealized compが十分に高ければ配布しない。前回紹介したXさんのような場合、refresherはinitial grantが無くなるまでまったくない。Google/FBの技術者には驚きの制度だろう。Amazonの技術者からすればその逆なのだ。
>> In France, after the new coronavirus was confirmed on January 24, 2020, a lot of harassment and discrimination against Asians occurred . It is aimed at Asians such as Chinese, Korean, Japanese, Vietnamese, Filipino , and taxis and trains that refuse to board Chinese, Korean, Japanese have appeared   ].
In the ranking of the number of infected people in the world, the United States is alone, with 1.34 million people, accounting for more than a quarter of the total infected people of 402 million people as of May 10.
I think that the trilingual diplomacy of Britain has created the situation in the Middle East, where terrorism is frequent nowadays, and has repeatedly carried out wrongdoing by repeatedly discriminating against blacks, Indians, and yellow races.
1 Most of what I'm about to write is no different from what I've said and done in the past. However, I have been asked the same question repeatedly, so I would like to reiterate it. We have received many inquiries from overseas as well, so we should have prepared the same content in English, but due to time constraints, I'm afraid I'll have to skip it. This article is designed to be read without basic knowledge of infectious diseases and jargon, but it is rather difficult to understand. Please forgive me for that.
2 The fact that the number of COVID-19 reports in Japan is very low compared to other countries is attracting attention from home and abroad. Is it true? It has been pointed out that the number of tests is so small that we may be misreading the actual number of infected people.
3 However, this point is wrong at various layers. In the first place, Japan does not aim to capture all the numbers of COVID-19. Whether it's administrative testing or insured care, the state basically has a testing strategy in mind to diagnose, hospitalize, and isolate critically ill patients who need to be hospitalized. It is natural that they "haven't figured it out" and they don't intend to. That's not a bad thing.In fact, the situation is the same in every country, large or small, and no country, whether in the United States, Europe, or Asia, is aiming to "capture the whole number.
The WHO is not asking for such a thing. But instead, Japan gives PCR to asymptomatic returnees and isolates asymptomatic test-positive people in hospital (wasn't it home for people with minor illnesses?). It has not been coherent in its principles. So, people get anxious because "we're not sure what they want to do". It's a failure in the press.
4 The difference between Korea and Japan is the "result" and not the "purpose". In South Korea, where the number of infected people had surged in one place, we had to focus on inspections in and around the area. If such a phenomenon (let's call it an overshoot) occurs in Japan, the number of inspections will increase. When the situation is different, arguing only on the basis of the number of tests without observing the situation is like trying to say, "That team made 50 sliding tackles while this team made only one," without watching a football game. In games where you don't have to slide (e.g., when you're in possession the whole time), even 0 times isn't a "mistake," and of course 50 times isn't a mistake.
There are many diseases for which the total number of patients is not known. In Japan, we do not have a "total" number of influenza cases, but only a fixed-point observation. Because that's enough information, both epidemiologically and in terms of infection control. There is no accurate data on how many cases of the common cold occur each year in Japan. It's also a mistake to say that you can tell by looking at the receipt data, because many cold patients (like me) don't see a doctor and wait until they are cured naturally. Not only in medicine, but also in economics and political science, data are mostly based on sampling to estimate population numbers, and "whole numbers" is an inefficient way of grasping the situation.
6 We have not seen the devastation in Japan as in Italy, Spain or New York City. There is no medical collapse in a critically ill patient, no use of the operating room as an ICU, no piling up of bodies on a skating rink with no place to put them. Even if the "numbers" are not known, it is a fact that the current situation in Japan (including Tokyo) is much better controlled than in other countries.
7 Even so, you may be interested in "Well, what about the actual situation? There are estimates. For example, Dr. Hiroshi Nishiura and his group estimate that the number of mild illnesses in Japan may be twice the reported number. The catch rate is 0.44, with a 95% confidence interval of 0.37-0.50.
8 Although the study was based on data from China, there is no guarantee that the Chinese COVID-19 demographic is the same as the Japanese one. Also, since the original study did not include asymptomatic patients or those with minor illnesses that did not require hospitalization, the number of infected patients estimated on that basis would inevitably be an underestimate. If you are more paranoid, it's not unreasonable to believe that "the Japanese and Chinese viruses are different because of the mutation" (although I don't think so).
9 This does not diminish the value of the paper itself. The model must always use existing parameters, and it is often impossible to prove the external validity of these parameters. If the underlying parameters are not reasonable, the predictions will not be correct. A model assumes a simplified world insofar as it is a model. A model without simplification, which is an adjectival contradiction.
To complain about these "assumptions" of the mathematical model is like complaining, for example, "You can't explain disease B," when a randomized controlled trial is conducted for disease A. This is a meaningless tirade against the honor of the industry.
A mathematical model that assumes a certain hypothesis should have internal academic validity, but it is the responsibility of the reader, as a resident of the real world, to appraise it in the real world.
Just as the RCT findings for disease A should not be used for disease B, it is natural to understand the limitations of the mathematical model and to be careful when applying it to the real world. For example, it would be wrong to read the paper and conclude that the total number of infected people in Tokyo is about 500 as of March 26.
11 People make mistakes. The models are also wrong. Being wrong is not a big deal. The problem is to notice your mistakes and make corrections. Already, a group at Imperial College London has admitted that its original estimate that the peak of the infection should be moderated was "wrong" and has revised its prediction that the ICU will soon fail if it does not fight the virus fairly aggressively.
I am currently working at a factory in a department where I work day shift and night shift. My workplace is in the countryside, where the nearest station is a station where only regular trains stop, and I live in a cheap apartment near a station where only regular trains stop. If I work the night shift, I have to wait for the train for 30 minutes no matter when it ends.
Factory work is boring. It just repeats the same process. The only way I can cope with boredom is to think while working, or to take advantage of the noisy environment and sing at a decent volume. I didn't want to spend 30 minutes of idle time after such boredom was over, I wanted to go home early, eat, drink and go to bed, and I had no other feelings.
About this time last year, I started writing down things I'd been thinking about in my workday when I was bored, as a 30-minute reprieve from boredom. I am not a smart man, as many factory workers probably are. The longest I've ever written is perhaps a two-page, one-line book report.I struggled to come up with the best way to express myself while I was on shift, and I wrote it down while smoking a cigarette in the smoking area near the station. I can write about 1,000 or 2,000 words, more than three times the length of two pages and one line, without any difficulty.
Thus, I started to use these 30 minutes only for writing. Since then, I've spent my days finding something to write about for those 30 minutes, figuring out how to write it during my shift, and actually writing it while waiting the train.
On the first day of December, it was decided that I would be reassigned to a department that did not have a night shift, starting in April. It's a full-time day job that I've been waiting for for the last year, but after April I might be away from writing. When I thought about this, I felt the urge to have someone else read my writing.
I started this writing on December 2, 9 night shifts = 4.5 hours, so far about 800 words. Oddly enough, it's close to two pages and one line. The moment I want someone to read my writing, I find it very difficult to write. However, I'm proud to say that this text makes a lot more sense than the two pages and one line I once wrote, and above all, I was never bored while writing it.