from mpl_toolkits.mplot3d import Axes3D
X, Y = np.meshgrid(x, y)
# Number Data of New Infection Patient
[40,112, 47, 46, 164,159, 90], # Apr27
[87, 57, 37, 23, 39, 36, 22], # May4
[ 48, 27, 16, 41, 35, 39, 35], # Jul15
[ 29, 31, 55, 48, 54, 57, 60], # Jul22
[131,266,250,367,463,472,292], # Jul27
ax.plot_wireframe(X, Y, Z)
If you’re not an athlete, and your heart rate is lower than average, you may be interested to discover that bradycardia, as it’s known, is more strongly correlated with psychopathy than smoking is with lung cancer.
I'm having a few days off so I want to spend the time learning Julia. I'm working mostly in R and Python, and my work involved a lot of Bayesian stuffs which I usually use either Stan or PyMC3 for. Recently I've been playing around with Julia, and I've heard a lot of praises for Turing.jl for probabilistic programming. I wonder if anyone here ever used it? What are some pros and cons against, say, Stan or PyMC3?
Turing.jl dev here. There are various differences between Turing, Stan and PyMC. Most importantly, Turing is only adding a thin layer to your Julia code, and you can, therefore, use any Julia code or library that exists in your models. This means you can easily use NN, the GPU, ODEs and whatever you like. By doing so, Turing is also more easily hackable. Another big difference is that Turing allows you to combine samplers and provides inference algorithms for continuous and discrete RVs. For the continuous case, we have an excellent implementation of Stans HMC and other variants, provided in a library that also can be used independently. The support for discrete RVs is mostly using particle Gibbs, but we are working on a JAGS style sampler atm. That said, Turing is much younger than the other PPLs. We probably lack specific tools, or you might run in some corner cases we didn’t think of, but we are working hard on getting bugs fixed ASAP and respond to questions quickly.
What's with that face? What's that look on your face? Open your mouth cunt and give me an answer. Open your mouth and put a sir on before and after you open your mouth and spit out your cum. Got it, Tadpole?
OK! we will now begin our morning erection summit. Speak in the language of the dick here. I want you to listen to me like you do when you listen to a hypnotic voice, with a little pussy juice coming out of your eardrums to get a good eardrum passage. That's good!
>> In France, after the new coronavirus was confirmed on January 24, 2020, a lot of harassment and discrimination against Asians occurred . It is aimed at Asians such as Chinese, Korean, Japanese, Vietnamese, Filipino , and taxis and trains that refuse to board Chinese, Korean, Japanese have appeared   ].
In the ranking of the number of infected people in the world, the United States is alone, with 1.34 million people, accounting for more than a quarter of the total infected people of 402 million people as of May 10.
I think that the trilingual diplomacy of Britain has created the situation in the Middle East, where terrorism is frequent nowadays, and has repeatedly carried out wrongdoing by repeatedly discriminating against blacks, Indians, and yellow races.
Bologna - From social media comes good news about the Coronavirus, perhaps decisive, which has scientific foundations and is disseminated by an authoritative doctor from Rizzoli of Bologna, Sandro Giannini. His is a highly qualified curriculum: Full Professor of Orthopedics and Traumatology and of Physical Medicine at the University of Bologna since 1989, director of Clinic I at the Rizzoli Orthopedic Institute and of the Gait Analysis Laboratory, partner in European projects and in national and international research programs, author of more than 600 presentations at national and international conferences and more than 400 articles in Science Citation Index journals. His message gives great hope. Let's read:
“I don't want to seem overwhelming to you, but I think I've demonstrated the cause of coronavirus lethality. Only at Blessed Matthew are there 2 cardiologists who turn over 150 beds to do echocardium with enormous effort and one is me. Terrible fatigue! However, of what some supposed, but could not be sure, we now have the first data. People go to resuscitation for generalized venous thromboembolism, especially pulmonary. If this were the case, resuscitations and intubations are of no use because first of all you have to dissolve, indeed prevent these thromboembolisms. If you ventilate a lung where blood does not reach, it is not needed! In fact 9 out of 10 die. Because the problem is cardiovascular, not respiratory! It is venous microthrombosis, not pneumonia that determines fatality!
And why are thrombi formed? Because inflammation, as per school text, induces thrombosis through a complex but well-known pathophysiological mechanism. Then? Contrary to what scientific literature, especially Chinese, said until mid-March, it was that anti-inflammatories should not be used. Now in Italy anti-inflammatories and antibiotics are used (as in the influences) and the number of inpatients collapses. Many deaths, even 40 years old, had a history of high fever for 10-15 days that was not treated properly. Here inflammation has destroyed everything and prepared the ground for thrombi formation. Because the main problem is not the virus, but the immune reaction that destroys the cells where the virus enters. In fact, our COVID departments have never entered patients with rheumatoid arthritis! Because they make cortisone, a powerful anti-inflammatory!
Therefore, hospitalizations in Italy are decreasing and it is becoming a disease that is treated at home. By taking care of it well at home, you avoid not only hospitalization, but also the thrombotic risk. It was not easy to understand it because the signs of microembolism have faded, even at the echocardium. But this weekend I compared the data of the first 50 patients between those who breathe badly and those who don't and the situation appeared very clear. For me you can go back to playing and reopen the business. Quarantine street. Not now. But time to publish this data. Vaccine can arrive calmly. In America and other states that follow the scientific literature that calls for NOT to use anti-inflammatories is a disaster! Worse than in Italy. And they are old and cheap drugs. " (Associated Medias - Red / Giut)
Bologna – Dai social arriva una buona notizia sul Coronavirus, forse risolutiva, che ha fondamenta scientifiche ed è diffusa da un medico autorevole del Rizzoli di Bologna, Sandro Giannini. Il suo è un curriculum molto qualificato: Professore ordinario di Ortopedia e Traumatologia e di Medicina Fisica presso l’Università di Bologna dal 1989, direttore della Clinica I presso l’Istituto Ortopedico Rizzoli e del Laboratorio di Gait Analysis, partner in progetti europei e in programmi di ricerca nazionali e internazionali, autore di più di 600 presentazioni a congressi nazionali ed internazionali e più di 400 articoli in riviste Science Citation Index. Il suo messaggio dà grande speranza. Leggiamolo:
“Non vorrei sembrarvi eccessivo ma credo di aver dimostrato la causa della letalità del coronavirus. Solo al Beato Matteo ci sono 2 cardiologi che girano su 150 letti a fare ecocardio con enorme fatica e uno sono io. Fatica terribile! Però, di quello che alcuni supponevano, ma non ne riuscivano a essere sicuri, ora abbiamo i primi dati. La gente va in rianimazione per tromboembolia venosa generalizzata, soprattutto polmonare. Se così fosse, non servono a niente le rianimazioni e le intubazioni perché innanzitutto devi sciogliere, anzi prevenire queste tromboembolie. Se ventili un polmone dove il sangue non arriva, non serve! Infatti muoiono 9 su 10. Perche il problema è cardiovascolare, non respiratorio! Sono le microtrombosi venose, non la polmonite a determinare la fatalità!
E perché si formano trombi? Perche l’infiammazione come da testo scolastico, induce trombosi attraverso un meccanismo fisiopatologico complesso ma ben noto. Allora? Contrariamente a quello che la letteratura scientifica, soprattutto cinese, diceva fino a metà marzo era che non bisognava usare antinfiammatori. Ora in Italia si usano antinfiammatori e antibiotici (come nelle influenze) e il numero dei ricoverati crolla. Molti morti, anche di 40 anni, avevano una storia di febbre alta per 10-15 giorni non curata adeguatamente. Qui l’infiammazione ha distrutto tutto e preparato il terreno alla formazione dei trombi. Perche il problema principale non è il virus, ma la reazione immunitaria che distrugge le cellule dove il virus entra. Infatti nei nostri reparti COVID non sono mai entrati malati di artrite reumatoide! Perche fanno il cortisone, un potente antinfiammatorio!
Pertanto, in Italia ospedalizzazioni si riducono e sta diventando una malattia che si cura a casa. Curandola bene a casa eviti non solo ospedalizzazione, ma anche il rischio trombotico. Non era facile capirlo perché i segni della microembolia sono sfumati, anche all’ecocardio. Ma questo week end ho confrontato i dati dei primi 50 pazienti tra chi respira male e chi no e la situazione è apparsa molto chiara. Per me si può tornare a giocare e riaprire l’attività commerciali. Via quarantena. Non subito. Ma il tempo di pubblicare questi dati. Vaccino può arrivare con calma. In America e altri stati che seguono la letteratura scientifica che invita a NON usare antinfiammatori e’ un disastro! Peggio che in Italia. E sono farmaci vecchi e che costano pochi euro.”
12 Dr. Hiroshi Nishiura is one of the few professionals of mathematical models of infectious diseases in Japan, and it is well known that his ability is outstanding. However, many people don't understand mathematical models themselves (I must confess that I can't say that I understand all of the findings because I'm not a professional of mathematical models either), so his findings and comments are easily deified. Because the contents of the mathematical model are a complete black box to many people, it makes it seem like the oracle is coming out like a shrine's oracle. Much of Japan's infection control policy relies on the Nishiura theory. So there is nothing wrong with that, but one of the problems in Japan is that there is no plan B in case plan A goes bust. Dr. Nishiura is an excellent scholar. It is not God. Hence the need to have that Plan B with the possibility of making a mistake. I am greatly concerned that bureaucrats and politicians who are prone to infallibilism will mistake science for an oracle. It is only when falsifiability is assured that science can continue to be scientific.
Mathematical models are the product of deductive methods. The deductive method is complemented by the inductive or abduction method, which is the basis of scholarship and the common sense of clinical medicine. It's a common occurrence in this industry that no matter how deducibly correct it may seem, it's actually not true. Even a huge intellect like Hegel or Marx can make a mistake by deduction alone.
I'm not saying don't use the model at all. I myself write a paper using a model. However, the model is not infallible, there are assumptions that are assumptions, and the assumptions are often wrong. Making use of Gram's stain means having full knowledge of what Gram's stain cannot do and does not understand, and Gram's stain cannot be used by Gram's stain universalists. It's the same thing. Mathematical models are also utilized in the UK, which is why Brits are very sceptical of their conclusions, and there are always counter-arguments and objections. It is a sound and scientific attitude.
15 Japan's "now" is a well-controlled state of infection, which is much better than Wuhan at its worst, or Italy, Spain, France, England, or New York at the present time. The problem is that it doesn't guarantee that it will "always work".
It is Tokyo that is of concern. The increase in reports of infection is not the only problem. The problem is that more and more infected people are unable to form clusters and cannot be traced. And the number of tests is much lower than that number of positive cases; it's too little that they only tested less than 100 people (the date of testing for the positives is unknown, but it's probably around here) to capture 47 infected people.
Again, it's not necessary to figure out all the infected people. However, it is troubling that the flow of infection, movement and clusters are out of sight. Therefore, the threshold for testing must be lowered in Tokyo. The threshold for testing varies with the circumstances. That's what I explained with the Korean example. Sticking to the Ministry of Health, Labour and Welfare's "standards" will lead to a misunderstanding of the phenomenon itself. Already in the Kansai region, infected people have been found with taste and smell abnormalities, and clusters have been detected from there. I would like to make more use of the athletic sensibilities of these clinicians. I'm not sure "where" in Tokyo is the barrier to lowering the number of inspections, but that barrier needs to be removed immediately.
17 This conceptual diagram that everyone is looking at - lowering the peak of the infection and shifting it to the side. This is all a product of deduction, and I don't know if it's really true. As mentioned above, the UK estimates already suggest that this is not enough. It is possible that the damage that was shifted to the side could simply be "extra-long damage".
And this is the key point: the idea of lowering the peak should not become the notion that the peak must be lowered, or the belief that the peak must be lowered, or the self-implication that the peak is not happening. In a pattern of Japanese failure to stick to Plan A, Diamond Princess allowed no-guard disembarkation by changing "secondary infection should not occur" to "it can't have happened". We need to keep our eyes on reality so that "peak shouldn't happen" doesn't become "I don't want to see a peak. Even if it is an inconvenient truth that we don't want to see.
19 Repeatedly. It's common knowledge in this industry that deductive methods are complemented by inductive methods. Nevertheless, PCR is often false-negative and has little power to determine the status of infection. That's why "testing everything" is so wrong. However, a serum test measuring immunoglobulin IgM and IgG would provide a more accurate picture of the "status of infection in the population. This, however, is not infallible. It is difficult to use for individual cases because it misses early infection, which is why it misses early HIV infection.Whether antibody testing is useful in individual cases remains to be tested, but it is well suited for epidemiological studies on a population basis. Roughly speaking, we can confirm whether the "infection is rampant" in Tokyo right now, or whether it's just an unfounded fear.
As a precedent, serology tests in London showed that the 2009 pandemic flu was 10 times more likely than previously predicted. Antibody testing is often performed after an outbreak, but now is a good time to examine COVID-19, which is becoming a chronic pandemic.
The UK is even more aggressive. The idea is to test for antibodies at home, and if they are found to be infected, they will use it as a basis for self-isolation at home. That strategy is flawed because with the lockdown in place, a negative test does not mean "no self-sequestration". However, the idea is that we want to control the infection as a whole, and I think it is worth considering.
Inductive legal confirmation of how many infections are occurring in Tokyo is necessary and useful. I'm not a prophet, so I don't know what the outcome will be.However, no matter what the outcome, scientists need to accept it and not hesitate to change their thesis and move on to Plan B in some cases. Scientists have to be coherent in their inconsistencies.They may not be coherent in form, but they must be coherent in principles and professionalism. Good faith in the facts.
L 感染が終息に向かっている (向かっていません)
天仰げ 空高く 今宵 星戻る
主が戻る 人よ知れ 新しき 恐れを
Hopes turn to black when they come back
真の名を 主は示す 闇を望め 希望はない
Ignorant fools, mankind now rules
Stars brightly burning, boiling and churning
Scary scary scary scary solstice
Up from the sea, from underground
主は戻り 人は知る 新しき 恐れを
天仰げ 空高く 今宵 星戻る
永劫は 終わった 我らの 主の目覚め
Ignorant fools, mankind now rules
Stars brightly burning, boiling and churning
Scary scary scary scary solstice
Up from the sea, from underground
(天仰げ 空高く 今宵 星戻る)
They will return