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Coronavirus: speranze dalla scoperta di Sandro Giannini, 10 Aprile, 2020
https://buongiornonews.it/coronavirus-una-speranza-dalla-scoperta-del-prof-giannini/
1) 英訳（Google translate を利用させて頂きました）
Coronavirus: hopes from the discovery of Sandro Giannini
Bologna - From social media comes good news about the Coronavirus, perhaps decisive, which has scientific foundations and is disseminated by an authoritative doctor from Rizzoli of Bologna, Sandro Giannini. His is a highly qualified curriculum: Full Professor of Orthopedics and Traumatology and of Physical Medicine at the University of Bologna since 1989, director of Clinic I at the Rizzoli Orthopedic Institute and of the Gait Analysis Laboratory, partner in European projects and in national and international research programs, author of more than 600 presentations at national and international conferences and more than 400 articles in Science Citation Index journals. His message gives great hope. Let's read:
“I don't want to seem overwhelming to you, but I think I've demonstrated the cause of coronavirus lethality. Only at Blessed Matthew are there 2 cardiologists who turn over 150 beds to do echocardium with enormous effort and one is me. Terrible fatigue! However, of what some supposed, but could not be sure, we now have the first data. People go to resuscitation for generalized venous thromboembolism, especially pulmonary. If this were the case, resuscitations and intubations are of no use because first of all you have to dissolve, indeed prevent these thromboembolisms. If you ventilate a lung where blood does not reach, it is not needed! In fact 9 out of 10 die. Because the problem is cardiovascular, not respiratory! It is venous microthrombosis, not pneumonia that determines fatality!
And why are thrombi formed? Because inflammation, as per school text, induces thrombosis through a complex but well-known pathophysiological mechanism. Then? Contrary to what scientific literature, especially Chinese, said until mid-March, it was that anti-inflammatories should not be used. Now in Italy anti-inflammatories and antibiotics are used (as in the influences) and the number of inpatients collapses. Many deaths, even 40 years old, had a history of high fever for 10-15 days that was not treated properly. Here inflammation has destroyed everything and prepared the ground for thrombi formation. Because the main problem is not the virus, but the immune reaction that destroys the cells where the virus enters. In fact, our COVID departments have never entered patients with rheumatoid arthritis! Because they make cortisone, a powerful anti-inflammatory!
Therefore, hospitalizations in Italy are decreasing and it is becoming a disease that is treated at home. By taking care of it well at home, you avoid not only hospitalization, but also the thrombotic risk. It was not easy to understand it because the signs of microembolism have faded, even at the echocardium. But this weekend I compared the data of the first 50 patients between those who breathe badly and those who don't and the situation appeared very clear. For me you can go back to playing and reopen the business. Quarantine street. Not now. But time to publish this data. Vaccine can arrive calmly. In America and other states that follow the scientific literature that calls for NOT to use anti-inflammatories is a disaster! Worse than in Italy. And they are old and cheap drugs. " (Associated Medias - Red / Giut)
———
2) 原文：イタリア語
Coronavirus: speranze dalla scoperta di Sandro Giannini
Bologna – Dai social arriva una buona notizia sul Coronavirus, forse risolutiva, che ha fondamenta scientifiche ed è diffusa da un medico autorevole del Rizzoli di Bologna, Sandro Giannini. Il suo è un curriculum molto qualificato: Professore ordinario di Ortopedia e Traumatologia e di Medicina Fisica presso l’Università di Bologna dal 1989, direttore della Clinica I presso l’Istituto Ortopedico Rizzoli e del Laboratorio di Gait Analysis, partner in progetti europei e in programmi di ricerca nazionali e internazionali, autore di più di 600 presentazioni a congressi nazionali ed internazionali e più di 400 articoli in riviste Science Citation Index. Il suo messaggio dà grande speranza. Leggiamolo:
“Non vorrei sembrarvi eccessivo ma credo di aver dimostrato la causa della letalità del coronavirus. Solo al Beato Matteo ci sono 2 cardiologi che girano su 150 letti a fare ecocardio con enorme fatica e uno sono io. Fatica terribile! Però, di quello che alcuni supponevano, ma non ne riuscivano a essere sicuri, ora abbiamo i primi dati. La gente va in rianimazione per tromboembolia venosa generalizzata, soprattutto polmonare. Se così fosse, non servono a niente le rianimazioni e le intubazioni perché innanzitutto devi sciogliere, anzi prevenire queste tromboembolie. Se ventili un polmone dove il sangue non arriva, non serve! Infatti muoiono 9 su 10. Perche il problema è cardiovascolare, non respiratorio! Sono le microtrombosi venose, non la polmonite a determinare la fatalità!
E perché si formano trombi? Perche l’infiammazione come da testo scolastico, induce trombosi attraverso un meccanismo fisiopatologico complesso ma ben noto. Allora? Contrariamente a quello che la letteratura scientifica, soprattutto cinese, diceva fino a metà marzo era che non bisognava usare antinfiammatori. Ora in Italia si usano antinfiammatori e antibiotici (come nelle influenze) e il numero dei ricoverati crolla. Molti morti, anche di 40 anni, avevano una storia di febbre alta per 10-15 giorni non curata adeguatamente. Qui l’infiammazione ha distrutto tutto e preparato il terreno alla formazione dei trombi. Perche il problema principale non è il virus, ma la reazione immunitaria che distrugge le cellule dove il virus entra. Infatti nei nostri reparti COVID non sono mai entrati malati di artrite reumatoide! Perche fanno il cortisone, un potente antinfiammatorio!
Pertanto, in Italia ospedalizzazioni si riducono e sta diventando una malattia che si cura a casa. Curandola bene a casa eviti non solo ospedalizzazione, ma anche il rischio trombotico. Non era facile capirlo perché i segni della microembolia sono sfumati, anche all’ecocardio. Ma questo week end ho confrontato i dati dei primi 50 pazienti tra chi respira male e chi no e la situazione è apparsa molto chiara. Per me si può tornare a giocare e riaprire l’attività commerciali. Via quarantena. Non subito. Ma il tempo di pubblicare questi dati. Vaccino può arrivare con calma. In America e altri stati che seguono la letteratura scientifica che invita a NON usare antinfiammatori e’ un disastro! Peggio che in Italia. E sono farmaci vecchi e che costano pochi euro.”
(Associated Medias – Red/Giut)
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3) 追記
これ↓はどうも違う、ということのようです。
FDAが、COVID-19への非ステロイド性抗炎症薬（NSAIDs）使用について助言, 2020年4月1日
